Predominance of the T14484C mutation in French-Canadian families with Leber hereditary optic neuropathy is due to a founder effect

Am J Hum Genet. 2000 Jan;66(1):332-5. doi: 10.1086/302716.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Canada / epidemiology
  • DNA Mutational Analysis
  • DNA, Mitochondrial / analysis
  • DNA, Mitochondrial / genetics*
  • Female
  • Founder Effect
  • France / ethnology
  • Humans
  • Male
  • Optic Atrophies, Hereditary / ethnology*
  • Optic Atrophies, Hereditary / genetics
  • Pedigree
  • Point Mutation

Substances

  • DNA, Mitochondrial