Selective plasma hydrolysis of glucocorticoid gamma-lactones and cyclic carbonates by the enzyme paraoxonase: an ideal plasma inactivation mechanism

J Med Chem. 2000 Jan 13;43(1):19-21. doi: 10.1021/jm990436t.

Authors

K Biggadike¹, R M Angell, C M Burgess, R M Farrell, A P Hancock, A J Harker, W R Irving, C Ioannou, P A Procopiou, R E Shaw, Y E Solanke, O M Singh, M A Snowden, R J Stubbs, S Walton, H E Weston

Affiliation

¹ Medicinal Chemistry, Enzyme Pharmacology, Biomet Doscovery and Potein Science Units, Glaxo Wellcome Research and Development, Medicines Research Centre, Hertsfordshire, UK. [email protected]

PMID: 10633034
DOI: 10.1021/jm990436t

No abstract available

MeSH terms

Aryldialkylphosphatase
Carbonates / blood
Carbonates / chemistry*
Esterases / blood*
Glucocorticoids / blood
Glucocorticoids / chemistry*
Humans
Hydrolysis
In Vitro Techniques
Lactones / blood
Lactones / chemistry*
Lung / metabolism
Prodrugs / chemistry*
Prodrugs / metabolism
Stereoisomerism
Subcellular Fractions / metabolism

Substances

Carbonates
Glucocorticoids
Lactones
Prodrugs
Esterases
Aryldialkylphosphatase