Abstract
The calcineurin gene was cloned and disrupted in serotype D strains of Cryptococcus neoformans. Serotype A and serotype D calcineurin mutants were inviable at 37 degrees C and avirulent in mice, whereas only serotype A mutants were cation stress sensitive. Thus, calcineurin plays conserved and divergent roles in serotype A and serotype D strains.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Base Sequence
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Calcineurin / genetics
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Calcineurin / physiology*
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Cryptococcus neoformans / classification
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Cryptococcus neoformans / growth & development
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Cryptococcus neoformans / pathogenicity*
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Mice
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Mice, Inbred BALB C
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Molecular Sequence Data
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Mutation
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Serotyping
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Virulence