Abstract
We investigated the effect of the systemic infusion of brain derived neurotrophic factor (BDNF) on the behavioral response in a rat neuropathic pain model. One microgram per hour infusion of BDNF significantly attenuated mechanical hyperalgesia tested by the pin-prick test, however, 20 microg/h-BDNF infusion, on the contrary, enhanced the response. Neither 0.5 nor 10 microg/h-BDNF infusion influenced the mechanical hyperalgesia. Mechanical allodynia and thermal hyperalgesia, tested using a von Frey filament (23.0 mN) and the plantar test, were not influenced by BDNF treatment. These data suggest that systemic BDNF treatment can specifically alter high-threshold mechanosensitivity.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain-Derived Neurotrophic Factor / administration & dosage
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Brain-Derived Neurotrophic Factor / pharmacology*
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Brain-Derived Neurotrophic Factor / therapeutic use
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Denervation
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Hot Temperature
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Hyperalgesia / drug therapy
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Hyperalgesia / etiology
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Hyperalgesia / physiopathology*
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Infusions, Parenteral
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Male
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Mechanoreceptors / drug effects*
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Neuralgia / drug therapy
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Neuralgia / etiology
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Neuralgia / physiopathology*
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Pain
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Rats
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Rats, Sprague-Dawley
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Recombinant Proteins / pharmacology
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Recombinant Proteins / therapeutic use
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Sensory Thresholds / drug effects*
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Spinal Nerves / injuries
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Stress, Mechanical*
Substances
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Brain-Derived Neurotrophic Factor
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Recombinant Proteins