MARs of antigen receptor and co-receptor genes

Crit Rev Eukaryot Gene Expr. 1999;9(3-4):295-310. doi: 10.1615/critreveukargeneexpr.v9.i3-4.140.

Abstract

MARs are cis-acting DNA sequences that function both negatively and positively in conjunction with transcriptional enhancers to regulate antigen receptor and co-receptor genes. Evidence exists that certain tissue-specific nuclear proteins are involved in this regulation, including SATB1, Bright, and Cux/CDP, possibly by modulating intranuclear gene location, histone acetylation, DNA methylation, and/or nucleosome positioning.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / genetics*
  • DNA / genetics*
  • DNA Methylation
  • Gene Expression Regulation / immunology
  • Humans
  • Nuclear Matrix / genetics*
  • Receptors, Antigen, T-Cell / genetics*
  • Transcription, Genetic

Substances

  • Receptors, Antigen, T-Cell
  • DNA