Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene

Y Deng; A Madan; A B Banta; C Friedman; B J Trask; L Hood; L Li

doi:10.1006/geno.1999.6045

Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene

Genomics. 2000 Jan 1;63(1):133-8. doi: 10.1006/geno.1999.6045.

Authors

Y Deng¹, A Madan, A B Banta, C Friedman, B J Trask, L Hood, L Li

Affiliation

¹ Department of Molecular Biotechnology, University of Washington, Seattle, Washington 98195, USA.

PMID: 10662552
DOI: 10.1006/geno.1999.6045

Abstract

The genomic sequence of the human Jagged2 (JAG2) gene, which encodes a ligand for the Notch receptors, was determined. The 30-kb DNA sequence spanning the JAG2 gene contains 26 exons and a putative promoter region. Several potential binding sites for transcription factors, including NF-kappab, E47, E12, E2F, Ets-1, MyoD, and OCT-1, were found in the human JAG2 promoter region. The JAG2 gene was also mapped to the chromosomal region 14q32 using fluorescence in situ hybridization.

MeSH terms

Base Sequence
Blotting, Northern
Carrier Proteins / genetics*
Carrier Proteins / metabolism
Chromosome Mapping
Chromosomes, Human, Pair 14*
Humans
In Situ Hybridization, Fluorescence
Intercellular Signaling Peptides and Proteins
Jagged-2 Protein
Ligands
Membrane Proteins / metabolism
Molecular Sequence Data
Organ Specificity
Polymerase Chain Reaction
Receptors, Notch
Sequence Analysis, DNA

Substances

Carrier Proteins
Intercellular Signaling Peptides and Proteins
JAG2 protein, human
Jagged-2 Protein
Ligands
Membrane Proteins
Receptors, Notch

Associated data

GENBANK/AF029778
GENBANK/AF111170