Variation of the relative biologic effectiveness with tumor size using accelerated helium ions

Acta Radiol Ther Phys Biol. 1976 Jun;15(3):233-40. doi: 10.3109/02841867609131960.

Abstract

The RBE of an accelerated helium ion beam was determined on murine osteosarcomas ranging in size from single cells to visibly detectable lung colonies of approximately 1 X 10(-2) mm3. That the RBE increased as tumor size increased provides some biologic basis for the selection of advanced cases of neoplasia for clinical trials using relatively high LET radiation sources.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cobalt Radioisotopes
  • Helium*
  • Ions
  • Lung Neoplasms / radiotherapy*
  • Mice
  • Neoplasm Metastasis
  • Neoplasms, Experimental / radiotherapy
  • Osteosarcoma / radiotherapy*
  • Radioisotope Teletherapy
  • Radioisotopes
  • Time Factors

Substances

  • Cobalt Radioisotopes
  • Ions
  • Radioisotopes
  • Helium