Titanium plate-screw systems for maxillofacial reconstruction and internal fixation were studied including examination of chemical components, measurement of mechanical natures, biomechanical and biological evaluation, in combination with retrospective analysis of 319 cases fixed by means of plate-screw appliances. The results demonstrated that all experimental data have satisfied basically the design and clinical requirements, with the exception of a weaker curve-resistance and fixative stability of miniplate as well as lower surface wear-resistance of pure titanium. So, further improvement is necessary. Additionally, the function classification and indication of plate-screw systems are discussed. The duration and condition of intermaxillary fixation is suggested. The complications and their causes are analysed through comparison among different fixation systems.