Treatment of dementia-associated agitation with gabapentin

D M Roane; T E Feinberg; L Meckler; C R Miner; A Scicutella; R N Rosenthal

doi:10.1176/jnp.12.1.40

Treatment of dementia-associated agitation with gabapentin

J Neuropsychiatry Clin Neurosci. 2000 Winter;12(1):40-3. doi: 10.1176/jnp.12.1.40.

Authors

D M Roane¹, T E Feinberg, L Meckler, C R Miner, A Scicutella, R N Rosenthal

Affiliation

¹ Department of Psychiatry and the Neurobehavior and Alzheimer's Disease Center, Beth Israel Medical Center, New York, NY 10003, USA.

PMID: 10678511
DOI: 10.1176/jnp.12.1.40

Abstract

The authors describe the use of gabapentin in the treatment of 4 outpatients with dementia-associated agitation. On the basis of clinical case reports and the Overt Agitation Severity Scale, all 4 patients had reduced agitation with gabapentin. Three of 4 patients were successfully titrated to a full dose of 2,400mg/day. These findings suggest a possible role for gabapentin in the behavioral management of patients with dementia.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Acetates / adverse effects
Acetates / therapeutic use*
Aged
Aged, 80 and over
Alzheimer Disease / diagnosis
Alzheimer Disease / drug therapy*
Amines*
Anticonvulsants / adverse effects
Anticonvulsants / therapeutic use*
Cyclohexanecarboxylic Acids*
Dementia, Multi-Infarct / diagnosis
Dementia, Multi-Infarct / drug therapy*
Female
Gabapentin
Humans
Male
Mental Status Schedule
Neurologic Examination / drug effects
Psychomotor Agitation / diagnosis
Psychomotor Agitation / drug therapy*
gamma-Aminobutyric Acid*

Substances

Acetates
Amines
Anticonvulsants
Cyclohexanecarboxylic Acids
gamma-Aminobutyric Acid
Gabapentin