Abstract
Mature and activated dendritic cells (CD83-positive DCs) are essential for the recruitment and survival of activated tumor-specific lymphocytes during carcinogenesis. The frequencies of CD83 positive DCs were almost same in peripheral blood from patients with hepatocellular carcinoma (HCC) and cirrhosis of liver (LC). However, the numbers of CD83 positive DCs in liver tissues were significant lower in HCC compared with LC (6.6+/-10.9 vs. 33.3+/-24 DCs/specimen, P<0.05). Most importantly, there were no CD83-positive DCs at cancer nodules in HCC. A role of infiltration of activated DCs in liver during hepatocarcinogenesis is shown.
MeSH terms
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Antigens, CD
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CD83 Antigen
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Carcinoma, Hepatocellular / blood
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Carcinoma, Hepatocellular / immunology*
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Carcinoma, Hepatocellular / pathology
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Cell Count
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Dendritic Cells / chemistry
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Dendritic Cells / immunology*
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Female
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Flow Cytometry
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HLA-DR Antigens / analysis
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Humans
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Immunoglobulins / analysis*
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Immunohistochemistry
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Liver Cirrhosis / blood
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Liver Cirrhosis / immunology
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Liver Cirrhosis / pathology
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Liver Neoplasms / blood
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Liver Neoplasms / immunology*
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Liver Neoplasms / pathology
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Male
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Membrane Glycoproteins / analysis*
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Middle Aged
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S100 Proteins / analysis
Substances
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Antigens, CD
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HLA-DR Antigens
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Immunoglobulins
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Membrane Glycoproteins
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S100 Proteins