Abstract
Twenty ventricular septal defect patients who underwent cardiopulmonary bypass (CPB) were divided into 1,6-diphosphate group and controlled group (10 cases each). Blood samples were taken at pre- and post-cardiopulmonary bypass 30 min, 6 h, and 24 h to determine lactate dehydrogenase enzyme(LDH), creatine kinase enzyme(CK) and its isoenzyme(CK-MB) levels. We found that 1,6-diphosphate decreased the increasing levels of LDH, CK, and CK-MB after cardiopulmonary bypass. It is suggested that 1,6-diphosphate may attenuate myocardial ischemia/reperfusion injuries during cardiopulmonary bypass.
Publication types
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Clinical Trial
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English Abstract
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Randomized Controlled Trial
MeSH terms
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Cardioplegic Solutions / administration & dosage*
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Cardiopulmonary Bypass
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Cardiovascular Agents / administration & dosage*
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Creatine Kinase / blood
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Fructosediphosphates / administration & dosage*
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Heart Septal Defects, Ventricular / enzymology
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Heart Septal Defects, Ventricular / surgery*
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Humans
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Isoenzymes
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L-Lactate Dehydrogenase / blood
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Myocardial Reperfusion Injury / prevention & control*
Substances
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Cardioplegic Solutions
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Cardiovascular Agents
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Fructosediphosphates
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Isoenzymes
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L-Lactate Dehydrogenase
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Creatine Kinase
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fructose-1,6-diphosphate