Abstract
Electron microscopy of negatively stained human foamy virus particles provides direct evidence for the trimeric nature of intact Env surface glycoproteins. Three-dimensional image reconstruction reveals that the Env trimer is a tapering spike 14 nm in length. The spikes were often arranged in hexagonal rings which shared adjacent Env trimers.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Gene Products, env / chemistry*
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Gene Products, env / ultrastructure
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Glycoproteins / chemistry
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Glycoproteins / ultrastructure
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Humans
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Protein Conformation
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Retroviridae Proteins / chemistry*
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Retroviridae Proteins / ultrastructure
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Spumavirus / ultrastructure*
Substances
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Gene Products, env
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Glycoproteins
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Retroviridae Proteins