Abstract
We present two cases of invasive aspergillosis in patients with acute myeloid leukemia. In neutropenic patients with antibiotic resistent fever, without specific symptoms or signs, invasive aspergillosis should be considered. Diagnostic approaches such as X-ray/CT-scan of the thorax and sinuses, relevant cultures and antigen detection should be performed. Due to diagnostic difficulties and the rapid progression of the infection empirical antifungal therapy should be given. During subsequent neutropenic episodes prophylactic antifungal therapy can possibly preempt recurrence.
MeSH terms
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Adult
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Antifungal Agents / administration & dosage
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Aspergillosis / diagnostic imaging*
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Aspergillosis / etiology
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Aspergillosis / immunology
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Diagnosis, Differential
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Female
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Humans
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Leukemia, Myeloid, Acute / complications
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Leukemia, Myeloid, Acute / immunology
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Leukemia, Myeloid, Acute / microbiology*
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Lung Diseases, Fungal / diagnostic imaging*
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Lung Diseases, Fungal / etiology
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Lung Diseases, Fungal / immunology
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Male
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Middle Aged
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Neutropenia / complications
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Neutropenia / immunology
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Neutropenia / microbiology*
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Opportunistic Infections / immunology
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Opportunistic Infections / microbiology*
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Radiography