3-Imidazolylmethylaminophenylsulfonyltetrahydroquinolines, a novel series of farnesyltransferase inhibitors

C Z Ding; J T Hunt; C Ricca; V Manne

doi:10.1016/s0960-894x(99)00686-1

3-Imidazolylmethylaminophenylsulfonyltetrahydroquinolines, a novel series of farnesyltransferase inhibitors

Bioorg Med Chem Lett. 2000 Feb 7;10(3):273-5. doi: 10.1016/s0960-894x(99)00686-1.

Authors

C Z Ding¹, J T Hunt, C Ricca, V Manne

Affiliation

¹ Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. [email protected]

PMID: 10698452
DOI: 10.1016/s0960-894x(99)00686-1

Abstract

Design, synthesis and structure-activity relationship of a series of 3-imidazolylmethylaminophenylsulfonyltetrahydroquinolines as farnesyltransferase inhibitors are presented. A working pharmacophore of inhibiting farnesyltransferase by this series of inhibitors is proposed.

MeSH terms

Alkyl and Aryl Transferases / antagonists & inhibitors*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Farnesyltranstransferase
Quinolines / chemistry
Quinolines / pharmacology*
Structure-Activity Relationship

Substances

Enzyme Inhibitors
Quinolines
Alkyl and Aryl Transferases
Farnesyltranstransferase