Abstract
Resistance to imipenem and meropenem was observed in 211 (16.5%) isolates of Pseudomonas aeruginosa recovered in a Greek university hospital during 1996 to 1998. In six isolates selected from throughout this period, high-level resistance to both carbapenems (MICs >/= 128 microg/ml) was associated with production of the class B beta-lactamase VIM-1. bla(VIM)-bearing isolates belonged to serotype O:12 and were indistinguishable by pulsed-field gel electrophoresis.
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins*
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Disease Outbreaks*
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Drug Resistance, Microbial
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Greece / epidemiology
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Hospitals, University
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Humans
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Imipenem / pharmacology*
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Inpatients
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Meropenem
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Microbial Sensitivity Tests
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Pseudomonas Infections / epidemiology*
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Pseudomonas Infections / microbiology
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Pseudomonas aeruginosa / classification*
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / isolation & purification
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Serotyping
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Thienamycins / pharmacology*
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beta-Lactamases / biosynthesis*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Thienamycins
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Imipenem
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beta-Lactamases
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carbapenemase
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Meropenem