Outbreak of infections caused by Pseudomonas aeruginosa producing VIM-1 carbapenemase in Greece

J Clin Microbiol. 2000 Mar;38(3):1290-2. doi: 10.1128/JCM.38.3.1290-1292.2000.

Abstract

Resistance to imipenem and meropenem was observed in 211 (16.5%) isolates of Pseudomonas aeruginosa recovered in a Greek university hospital during 1996 to 1998. In six isolates selected from throughout this period, high-level resistance to both carbapenems (MICs >/= 128 microg/ml) was associated with production of the class B beta-lactamase VIM-1. bla(VIM)-bearing isolates belonged to serotype O:12 and were indistinguishable by pulsed-field gel electrophoresis.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins*
  • Disease Outbreaks*
  • Drug Resistance, Microbial
  • Greece / epidemiology
  • Hospitals, University
  • Humans
  • Imipenem / pharmacology*
  • Inpatients
  • Meropenem
  • Microbial Sensitivity Tests
  • Pseudomonas Infections / epidemiology*
  • Pseudomonas Infections / microbiology
  • Pseudomonas aeruginosa / classification*
  • Pseudomonas aeruginosa / drug effects
  • Pseudomonas aeruginosa / isolation & purification
  • Serotyping
  • Thienamycins / pharmacology*
  • beta-Lactamases / biosynthesis*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Thienamycins
  • Imipenem
  • beta-Lactamases
  • carbapenemase
  • Meropenem