Lipid A and related compounds. XXXVII. Determination of favorable binding linkages of lipid A analog to antigen moiety for synthetic vaccines

Chem Pharm Bull (Tokyo). 2000 Jan;48(1):32-40. doi: 10.1248/cpb.48.32.

Abstract

For the determination of favorable binding linkages of lipid A analog as a synthetic immunoadjuvant to the antigen moiety for synthetic vaccines, new N-acylated L-serine-containing D-glucosamine analogs (Type A, B, C) were synthesized and their mitogenicities were examined. Among chemically synthesized compounds (6-15, 30), compound 8 for Type B exhibited the most potent mitogenicity.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antigens, Bacterial / chemistry*
  • Lipid A / analogs & derivatives*
  • Lipid A / chemistry*
  • Lipid A / metabolism
  • Lipopolysaccharides / chemistry
  • Mice
  • Mice, Inbred C3H
  • Spleen / cytology
  • Spleen / drug effects
  • Spleen / metabolism
  • Thymidine / metabolism
  • Vaccines, Synthetic / chemistry*
  • Vaccines, Synthetic / metabolism

Substances

  • Antigens, Bacterial
  • Lipid A
  • Lipopolysaccharides
  • Vaccines, Synthetic
  • Thymidine