Synthesis of peptides mimicking chemokine receptor CCR5 and their inhibitory effects against HIV-1 infection

K Konishi; K Ikeda; K Achiwa; H Hoshino; K Tanaka

doi:10.1248/cpb.48.308

Synthesis of peptides mimicking chemokine receptor CCR5 and their inhibitory effects against HIV-1 infection

Chem Pharm Bull (Tokyo). 2000 Feb;48(2):308-9. doi: 10.1248/cpb.48.308.

Authors

K Konishi¹, K Ikeda, K Achiwa, H Hoshino, K Tanaka

Affiliation

¹ School of Pharmaceutical Sciences, University of Shizuoka, Japan.

PMID: 10705530
DOI: 10.1248/cpb.48.308

Abstract

Peptides mimicking chemokine receptor CCR5 were synthesized and their anti-HIV-1 activities evaluated. Prepared compounds, especially a sulfated derivatives, showed significant anti-HIV-1 activities. Furthermore, a hybrid molecule linked to an N-carbomethoxycarbonyl-prolyl-phenylalanine (CPF) moiety had a greater effect.

MeSH terms

Amino Acid Sequence
Anti-HIV Agents / chemical synthesis*
Anti-HIV Agents / pharmacology*
HIV Envelope Protein gp120 / drug effects
HIV Infections / drug therapy*
HIV-1*
Humans
Molecular Mimicry
Molecular Sequence Data
Peptides / chemical synthesis*
Peptides / pharmacology*
Receptors, CCR5 / chemistry*
Receptors, CCR5 / drug effects

Substances

Anti-HIV Agents
HIV Envelope Protein gp120
Peptides
Receptors, CCR5