Abstract
Antigen-presenting cells work to present peptides derived from exogenous and endogenous antigens to circulating T cells, sparking off an immune response. Dendritic cells are unique amongst antigen-presenting cells, not least for their newly described ability to circumvent the need to internalize exogenous antigens before presenting them.
MeSH terms
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Animals
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Antigen Presentation / immunology*
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Antigens / immunology
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Antigens / metabolism
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B-Lymphocytes / immunology
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Dendritic Cells / immunology
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Dendritic Cells / metabolism*
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Endosomes / immunology
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Endosomes / metabolism
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Extracellular Space / enzymology
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Extracellular Space / immunology
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Histocompatibility Antigens Class I / metabolism
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Histocompatibility Antigens Class II / metabolism
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Humans
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Ligands
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Macrophages / immunology
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Macrophages / metabolism
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Mice
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Models, Immunological
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Serine Endopeptidases / metabolism
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T-Lymphocytes / immunology
Substances
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Antigens
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Histocompatibility Antigens Class I
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Histocompatibility Antigens Class II
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Ligands
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Serine Endopeptidases