Abstract
B-1 cells differ from conventional peripheral B cells (B-2) by anatomical location, surface marker expression, antibody repertoire and growth properties. The lineage hypothesis of B-1 cell development attributes the properties of B-1 cells to their unique origin. The induced differentiation hypothesis suggests the surface-immunoglobulin-driven development of B-1 cells from common B-1/B-2 cell progenitors. In both models self-antigen-induced signalling plays the central role in positive selection of B-1 cells. The ability of B-1 cells to be positively selected by self-antigens raises questions about the mechanism of this phenomenon.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigens, Differentiation, B-Lymphocyte / immunology
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Autoantibodies / biosynthesis
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Autoantigens / immunology*
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Autoimmunity*
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B-Lymphocyte Subsets / drug effects
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B-Lymphocyte Subsets / immunology*
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CD5 Antigens / immunology
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Cell Differentiation
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Cell Lineage
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Clonal Deletion
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Gene Rearrangement, B-Lymphocyte, Heavy Chain
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Hematopoietic Stem Cells / cytology
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Humans
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Immunoglobulin Heavy Chains / genetics
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Lymphocyte Activation / drug effects
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Mice
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Mice, Transgenic
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Models, Immunological*
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Phorbol Esters / pharmacology
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Receptors, Antigen, B-Cell / genetics
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Receptors, Antigen, B-Cell / immunology*
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Signal Transduction
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Thy-1 Antigens / genetics
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Thy-1 Antigens / immunology
Substances
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Antigens, Differentiation, B-Lymphocyte
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Autoantibodies
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Autoantigens
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CD5 Antigens
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Immunoglobulin Heavy Chains
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Phorbol Esters
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Receptors, Antigen, B-Cell
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Thy-1 Antigens