1-(2-Nitrophenyl)thiosemicarbazides: a novel class of potent, orally active non-peptide antagonist for the bradykinin B(2) receptor

J Med Chem. 2000 Mar 9;43(5):769-71. doi: 10.1021/jm991155o.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Analgesics, Non-Narcotic / chemical synthesis*
  • Analgesics, Non-Narcotic / chemistry
  • Analgesics, Non-Narcotic / metabolism
  • Analgesics, Non-Narcotic / pharmacology
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / metabolism
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Bradykinin Receptor Antagonists*
  • Cell Line
  • Hyperalgesia / chemically induced
  • Hyperalgesia / drug therapy
  • Proline / analogs & derivatives
  • Radioligand Assay
  • Rats
  • Receptor, Bradykinin B2
  • Structure-Activity Relationship
  • Thiourea / analogs & derivatives

Substances

  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents, Non-Steroidal
  • Bradykinin Receptor Antagonists
  • N-(4-(2-(2-((2-dmethylaminoethyl)methylamino)ethylaminocarbonyl)pyrrolidinylsulfonyl)-2-nitrophenylamino)-N'-diphenylmethylthiourea
  • Receptor, Bradykinin B2
  • Proline
  • Thiourea