Successful non-surgical treatment of Candida tropicalis endocarditis with liposomal amphotericin-B (AmBisome)

Scand J Infect Dis. 2000;32(1):86-9. doi: 10.1080/00365540050164281.

Abstract

Fungal endocarditis in children is most commonly a complication of palliative or curative surgery for congenital heart disease, rheumatic valvulitis and prolonged indwelling central venous and umbilical catheters. We describe here the case of a 3-y-old patient with chronic diarrhoea and prolonged total parenteral alimentation who developed severe C. tropicalis endocarditis and was treated successfully using a liposomal preparation of amphotericin-B (AmBisome) without surgical intervention.

Publication types

  • Case Reports

MeSH terms

  • Amphotericin B / administration & dosage
  • Amphotericin B / therapeutic use*
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / therapeutic use*
  • Candida / isolation & purification
  • Candidiasis / drug therapy*
  • Child, Preschool
  • Chronic Disease
  • Diarrhea / complications
  • Drug Carriers
  • Echocardiography
  • Endocarditis / diagnostic imaging
  • Endocarditis / drug therapy*
  • Endocarditis / microbiology
  • Heart Atria / diagnostic imaging
  • Heart Atria / microbiology
  • Humans
  • Liposomes
  • Male
  • Treatment Outcome

Substances

  • Antifungal Agents
  • Drug Carriers
  • Liposomes
  • Amphotericin B