Abstract
Sulphur-containing derivatives structurally related to the insect growth regulator fenoxycarb were shown to be extremely active antiproliferative agents against the amastigote form of Trypanosoma cruzi in in vitro assays. All of these drugs had previously been proved to be remarkably potent growth inhibitors against the epimastigote form of the parasite.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Carbamates / chemistry*
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Cells, Cultured
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Phenyl Ethers / chemistry
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Phenyl Ethers / pharmacology*
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Phenylcarbamates*
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Structure-Activity Relationship
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Sulfides / chemistry
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Sulfides / pharmacology*
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Trypanocidal Agents / chemistry
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Trypanocidal Agents / pharmacology*
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Trypanosoma cruzi / drug effects*
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Trypanosoma cruzi / growth & development
Substances
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Carbamates
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Phenyl Ethers
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Phenylcarbamates
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Sulfides
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Trypanocidal Agents
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fenoxycarb