Abstract
Hexane, ethyl acetate and methanol extracts of Annona muricata pericarp were tested in vitro against Leishmania braziliensis and L. panamensis promastigotes, and against cell line U-937. The ethyl acetate extract was more active than the other extracts and even of Glucantime used as reference substance. Its fractionation led to the isolation of three acetogenins--annonacin, annonacin A and annomuricin A.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
4-Butyrolactone / analogs & derivatives*
-
4-Butyrolactone / chemistry
-
Animals
-
Antiprotozoal Agents / pharmacology*
-
Antiprotozoal Agents / toxicity
-
Cell Line / drug effects
-
Furans / chemistry
-
Humans
-
Lactones / chemistry
-
Leishmania / drug effects*
-
Plant Extracts / pharmacology*
-
Plant Extracts / toxicity
-
Plants, Medicinal*
Substances
-
Antiprotozoal Agents
-
Furans
-
Lactones
-
Plant Extracts
-
annomuricin A
-
annonacin
-
4-Butyrolactone