Abstract
A phytochemical investigation of the chloroform leaf extract of Alchornea latifolia has been undertaken. Along with the triterpenoids taraxerone, friedelin, epifriedelinol, and taraxerol, the plant also contains seco-3,4-friedelin (dihydroputranjivic acid) (1) and seco-3,4-taraxerone (2). These A-ring-opened triterpenoids show in vitro cytotoxic activity against Hep-G2 and A-431 human cancer cell lines and are potent inhibitors of topoisomerase II.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Euphorbiaceae*
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Humans
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Medicine, African Traditional
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Microbial Sensitivity Tests
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Oleanolic Acid / analogs & derivatives*
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Oleanolic Acid / chemistry
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Oleanolic Acid / pharmacology*
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Phytotherapy
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Leaves
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Plants, Medicinal*
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Staphylococcus aureus / drug effects
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Streptococcus pneumoniae / drug effects
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Triterpenes / chemistry
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Triterpenes / pharmacology*
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Tumor Cells, Cultured / drug effects
Substances
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Plant Extracts
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Triterpenes
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Oleanolic Acid
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friedelin
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taraxerone