Abstract
A 72-year-old man was admitted to our hospital because of lumbago and numbness of legs. Tumor invasion at the fourth lumbar vertebra was revealed. Immunohistochemistry using specific antibodies against each heavy and light chain of immunoglobulin revealed that the myeloma cells in bone marrow were all IgA-lambda type whereas they were all positive for IgG-kappa type in a tumor of the fourth lumbar vertebra. These data indicate that the patient had IgG-kappa/IgA-lambda biclonal myeloma. Different phenotypes of M-proteins and distinct proliferating sites for two clones suggest that they may have resulted from two independent transforming events.
MeSH terms
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Aged
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Antibodies, Anti-Idiotypic / analysis
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Biopsy
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Diagnosis, Differential
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Fractures, Spontaneous / diagnosis
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Fractures, Spontaneous / etiology
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Humans
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Immunoelectrophoresis
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Immunoglobulin A / blood*
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Immunoglobulin A / immunology
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Immunoglobulin G / blood*
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Immunoglobulin G / immunology
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Immunoglobulin kappa-Chains / blood*
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Immunoglobulin kappa-Chains / immunology
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Immunoglobulin lambda-Chains / blood*
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Immunoglobulin lambda-Chains / immunology
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Lumbar Vertebrae / diagnostic imaging
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Lumbar Vertebrae / injuries
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Lumbar Vertebrae / pathology
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Magnetic Resonance Imaging
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Male
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Multiple Myeloma / blood*
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Multiple Myeloma / complications
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Multiple Myeloma / diagnosis
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Spinal Fractures / diagnosis
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Spinal Fractures / etiology
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Tomography, X-Ray Computed
Substances
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Antibodies, Anti-Idiotypic
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Immunoglobulin A
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Immunoglobulin G
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Immunoglobulin kappa-Chains
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Immunoglobulin lambda-Chains