One antigen mismatched related donor bone marrow transplant in a patient with acute lymphoblastic leukaemia and beta-thalassaemia major: potential cure of both marrow disorders

P D Kottaridis; K Peggs; A Lawrence; S Verfuerth; R Chatterjee; P Telfer; J B Porter; S Mackinnon; A H Goldstone

doi:10.1038/sj.bmt.1702213

One antigen mismatched related donor bone marrow transplant in a patient with acute lymphoblastic leukaemia and beta-thalassaemia major: potential cure of both marrow disorders

Bone Marrow Transplant. 2000 Mar;25(6):677-8. doi: 10.1038/sj.bmt.1702213.

Authors

P D Kottaridis¹, K Peggs, A Lawrence, S Verfuerth, R Chatterjee, P Telfer, J B Porter, S Mackinnon, A H Goldstone

Affiliation

¹ Department of Haematology, University College London Hospitals, London, UK.

PMID: 10734304
DOI: 10.1038/sj.bmt.1702213

Abstract

We report a case of a 34-year-old man with T-ALL and beta-thalassaemia major who underwent a one antigen mismatched related donor bone marrow transplant. Five months post transplant chimeric studies revealed full donor haemopoiesis and the patient remains leukaemia and thalassaemia free at 12 months post transplant. Cumulative risk factors contributing to the increased transplant-related mortality in patients with two different marrow disorders are discussed.

Publication types

Case Reports

MeSH terms

Adult
Blood Grouping and Crossmatching / adverse effects*
Bone Marrow Diseases / immunology
Bone Marrow Diseases / therapy
Bone Marrow Transplantation / adverse effects
Bone Marrow Transplantation / immunology*
Disease-Free Survival
Greece / ethnology
Humans
Isoantigens / adverse effects
Male
Microsatellite Repeats
Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy*
Risk Factors
Tissue Donors
Transplantation Chimera
Transplantation, Homologous
beta-Thalassemia / complications
beta-Thalassemia / immunology
beta-Thalassemia / therapy*

Substances

Isoantigens