Abstract
We report a case of a 50-year-old man with chronic viral hepatitis B presenting with a primary hepatic lymphoma of mucosa-associated lymphoid tissue, revealed clinically by a pedicular nodal mass. The liver biopsy showed an active chronic hepatitis and a dense portal lymphoid infiltrate with centrocyte-like cells inducing typical biliary lympho-epithelial lesions. The lymph-node biopsy revealed a marginal zone lymphoma pattern. A monoclonal rearrangement of the immunoglobulin heavy chain gene was detected in the lymph node by polymerase chain reaction. This case of primary hepatic mucosa-associated lymphoid tissue lymphoma confirms that the liver also contains mucosa-associated lymphoid tissue, in which low grade lymphoma can arise.
Publication types
-
Case Reports
-
English Abstract
-
Review
MeSH terms
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
-
Biopsy
-
Cyclophosphamide / administration & dosage
-
Doxorubicin / administration & dosage
-
Hepatitis B, Chronic / complications
-
Hepatitis B, Chronic / pathology
-
Humans
-
Immunoglobulin Heavy Chains / genetics
-
Liver Neoplasms / drug therapy
-
Liver Neoplasms / genetics
-
Liver Neoplasms / immunology
-
Liver Neoplasms / pathology*
-
Lymph Nodes / pathology
-
Lymphatic Metastasis
-
Lymphoma, B-Cell, Marginal Zone / drug therapy
-
Lymphoma, B-Cell, Marginal Zone / genetics
-
Lymphoma, B-Cell, Marginal Zone / immunology
-
Lymphoma, B-Cell, Marginal Zone / pathology*
-
Male
-
Middle Aged
-
Prednisone / administration & dosage
-
Vincristine / administration & dosage
Substances
-
Immunoglobulin Heavy Chains
-
Vincristine
-
Doxorubicin
-
Cyclophosphamide
-
Prednisone