Antitumour benzothiazoles. Part 10: the synthesis and antitumour activity of benzothiazole substituted quinol derivatives

G Wells; T D Bradshaw; P Diana; A Seaton; D F Shi; A D Westwell; M F Stevens

doi:10.1016/s0960-894x(00)00027-5

Antitumour benzothiazoles. Part 10: the synthesis and antitumour activity of benzothiazole substituted quinol derivatives

Bioorg Med Chem Lett. 2000 Mar 6;10(5):513-5. doi: 10.1016/s0960-894x(00)00027-5.

Authors

G Wells¹, T D Bradshaw, P Diana, A Seaton, D F Shi, A D Westwell, M F Stevens

Affiliation

¹ Cancer Research Laboratories, School of Pharmaceutical Sciences, University of Nottingham, UK.

PMID: 10743960
DOI: 10.1016/s0960-894x(00)00027-5

Abstract

The synthesis of a series of new antitumour agents, the benzothiazole substituted quinol ethers and esters, is reported via the hypervalent iodine mediated oxidation of hydroxylated 2-phenylbenzothiazoles. The products were found to be active in vitro against human colon and breast cancer cell lines with IC50 values in the nanomolar range.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology
Breast Neoplasms / drug therapy
Breast Neoplasms / pathology
Colonic Neoplasms / drug therapy
Colonic Neoplasms / pathology
Drug Screening Assays, Antitumor
HT29 Cells
Humans
Hydroquinones / chemical synthesis*
Hydroquinones / pharmacology
Oxidation-Reduction
Thiazoles / chemical synthesis*
Thiazoles / pharmacology
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Hydroquinones
Thiazoles