Abstract
Recent studies suggest that the cytoplasmic tail of the Crumbs protein establishes membrane territories in polarised epithelial cells by stabilising a PDZ-domain protein complex. The isolation of a human Crumbs homologue required for normal vision revives questions about the role of Crumbs in cell-cell interactions.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alternative Splicing
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Animals
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Cell Polarity / physiology*
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Drosophila Proteins*
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Humans
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Membrane Proteins / genetics
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Membrane Proteins / physiology*
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Protein Isoforms / genetics
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Protein Isoforms / physiology
Substances
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Drosophila Proteins
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Membrane Proteins
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Protein Isoforms
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crb protein, Drosophila