Abstract
In February 1998, 195 patients in the geriatric department of a French hospital were screened for the presence of co-amoxiclav-resistant Klebsiella pneumoniae. Eleven co-amoxiclav-resistant isolates obtained all produced an identical IRT-2 beta-lactamase. These K. pneumoniae isolates were clonally related and harboured a c. 55 kb non-conjugative plasmid encoding a non-class-1 integron-located blaIRT-2 gene. This study underlines that geriatric departments may be a reservoir for antibiotic-resistant strains and that IRT beta-lactamase-producing strains may be nosocomial pathogens.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amoxicillin-Potassium Clavulanate Combination / pharmacology
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Bacterial Proteins*
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Cross Infection / microbiology*
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DNA, Bacterial / genetics
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Drug Resistance, Microbial
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Electroporation
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France
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Geriatrics
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Hospital Departments
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In Situ Hybridization
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Isoelectric Focusing
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Klebsiella Infections / microbiology*
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Klebsiella pneumoniae / drug effects*
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Klebsiella pneumoniae / genetics
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Klebsiella pneumoniae / metabolism
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Microbial Sensitivity Tests
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Molecular Epidemiology
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Phenotype
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Reverse Transcriptase Polymerase Chain Reaction
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
Substances
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Bacterial Proteins
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DNA, Bacterial
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Amoxicillin-Potassium Clavulanate Combination
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TEM24 beta-lactamase
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beta-lactamase IRT-2
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beta-Lactamases