Abstract
In a prospective study of acute pharyngitis in Italian children, 69 (38.3%) of 180 isolates of Streptococcus pyogenes were resistant to macrolides. S. pyogenes was eradicated in 12 (63.1%) of 19 patients with erythromycin-resistant S. pyogenes treated with clarithromycin and in 22 (88%) of 25 patients with erythromycin-susceptible strains. The constitutive-resistant phenotype was correlated with failure of macrolide treatment.
MeSH terms
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Adolescent
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Anti-Bacterial Agents / pharmacology*
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Child
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Child, Preschool
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Clarithromycin / therapeutic use
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Drug Resistance, Microbial
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Erythromycin / pharmacology*
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Humans
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Infant
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Italy
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Microbial Sensitivity Tests
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Pharyngitis / drug therapy*
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Pharyngitis / microbiology*
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Phenotype
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Prospective Studies
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Streptococcal Infections / drug therapy*
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Streptococcal Infections / microbiology*
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Streptococcus pyogenes / drug effects*
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Streptococcus pyogenes / isolation & purification
Substances
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Anti-Bacterial Agents
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Erythromycin
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Clarithromycin