Abstract
29 oral melanomas were stained immunohistochemically for the GADD34, GADD45 and GADD153. GADD34 was found in 5/29 melanomas and its expression did not exceed 21%, averaging 4.1% of melanoma cells. GADD45 was observed in 8/29 oral melanomas and cell positivity averaged 2.8%. GADD153 was found in 2/29 melanomas and the percentage of positive cells ranged between 0 and 31%, averaging 1.2%. Not one significant correlation between GADD genes in oral melanomas was found. Loss of GADD gene expression and lack of correlation between them show advanced disturbances in their cooperation, leading to a high genetic instability of oral melanoma cells.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Antigens, Differentiation
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Biomarkers, Tumor
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CCAAT-Enhancer-Binding Proteins*
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Cell Cycle Proteins
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Cell Nucleus
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DNA Damage*
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DNA-Binding Proteins / genetics
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Female
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GADD45 Proteins
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Gene Expression Regulation, Neoplastic*
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Humans
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Intracellular Signaling Peptides and Proteins
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Male
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Melanoma / genetics*
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Middle Aged
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Mouth Neoplasms / genetics*
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Protein Phosphatase 1
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Proteins / genetics
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Transcription Factor CHOP
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Transcription Factors / genetics
Substances
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Antigens, Differentiation
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Biomarkers, Tumor
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CCAAT-Enhancer-Binding Proteins
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Cell Cycle Proteins
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DDIT3 protein, human
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DNA-Binding Proteins
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Intracellular Signaling Peptides and Proteins
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Proteins
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Transcription Factors
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Transcription Factor CHOP
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PPP1R15A protein, human
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Protein Phosphatase 1