CD14, new aspects of ligand and signal diversity

Microbes Infect. 2000 Mar;2(3):295-304. doi: 10.1016/s1286-4579(00)00298-7.

Abstract

The glycosyl-phosphatidylinositol-linked glycoprotein CD14 is expressed in myeloid cells and serum. It binds Gram-negative and -positive bacterial cell wall components and endogenous phospholipids. Toll-like receptors, NF-kappaB and MAP kinases participate in CD14 signaling of inflammation. Alterations of CD14 in inflammatory diseases support a pathogenic role for this microbial receptor.

Publication types

  • Review

MeSH terms

  • Animals
  • CHO Cells
  • Cell Membrane / immunology
  • Cricetinae
  • Drosophila Proteins*
  • Humans
  • Leukocytes / immunology
  • Ligands
  • Lipopolysaccharide Receptors / genetics
  • Lipopolysaccharide Receptors / immunology*
  • Lipopolysaccharide Receptors / metabolism
  • Lipopolysaccharides / immunology
  • Macrophages / immunology
  • Membrane Glycoproteins / immunology
  • Receptors, Cell Surface / immunology
  • Shock, Septic / immunology
  • Signal Transduction / immunology*
  • Systemic Inflammatory Response Syndrome / immunology
  • Toll-Like Receptors

Substances

  • Drosophila Proteins
  • Ligands
  • Lipopolysaccharide Receptors
  • Lipopolysaccharides
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptors