Characterization of JDP genes, an evolutionarily conserved J domain-only protein family, from human and moths

Biochim Biophys Acta. 2000 Apr 25;1491(1-3):355-63. doi: 10.1016/s0167-4781(00)00047-6.

Abstract

We characterized evolutionarily conserved J domain containing protein (JDP) genes from human, Bombyx mori, and Manduca sexta. Each of the JDP proteins contains a J domain at its N-terminus and a highly conserved C-terminal domain. Southern blot analysis revealed that the human JDP1 gene is present as a single copy in the human genome. Expression was higher in brain, heart, and testis than in kidney or stomach. Human JDP1 was mapped in silico to chromosome 10q21.1, which exhibits a conserved synteny with the central region of mouse chromosome 10. Drosophila jdp is located at 99F4-99F11 on the right arm of the third chromosome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Bombyx
  • Chromosome Mapping
  • Chromosomes, Human, Pair 10
  • Evolution, Molecular
  • Expressed Sequence Tags
  • Humans
  • Molecular Sequence Data
  • Moths
  • Phylogeny
  • Repressor Proteins / chemistry
  • Repressor Proteins / genetics*
  • Sequence Alignment

Substances

  • DNAJC12 protein, human
  • JDP2 protein, human
  • Jundp2 protein, mouse
  • Repressor Proteins

Associated data

  • GENBANK/AF176012
  • GENBANK/AF176013
  • GENBANK/AF176014
  • GENBANK/AF176015
  • GENBANK/AF192462
  • GENBANK/AF192463