Eryloside F, a novel penasterol disaccharide possessing potent thrombin receptor antagonist activity

P Stead; S Hiscox; P S Robinson; N B Pike; P J Sidebottom; A D Roberts; N L Taylor; A E Wright; S A Pomponi; D Langley

doi:10.1016/s0960-894x(00)00063-9

Eryloside F, a novel penasterol disaccharide possessing potent thrombin receptor antagonist activity

Bioorg Med Chem Lett. 2000 Apr 3;10(7):661-4. doi: 10.1016/s0960-894x(00)00063-9.

Authors

P Stead¹, S Hiscox, P S Robinson, N B Pike, P J Sidebottom, A D Roberts, N L Taylor, A E Wright, S A Pomponi, D Langley

Affiliation

¹ Bioprocessing Unit, Glaxo-Wellcome Medicines Research Centre, Stevenage, Herts, UK. [email protected]

PMID: 10762048
DOI: 10.1016/s0960-894x(00)00063-9

Abstract

We report the discovery of Eryloside F, a novel disaccharide of the steroidal carboxylic acid penasterol, isolated from an extract of the marine sponge Erylus formosus. The compound is a potent thrombin receptor antagonist, and furthermore inhibits human platelet aggregation in vitro.

MeSH terms

Animals
HeLa Cells
Humans
Lanosterol / analogs & derivatives
Lanosterol / chemistry
Lanosterol / pharmacology
Porifera / chemistry*
Receptors, Thrombin / antagonists & inhibitors*
Saponins / chemistry
Saponins / pharmacology*

Substances

Receptors, Thrombin
Saponins
eryloside F
penasterol
Lanosterol