Differential expression of chemokine receptor CXCR4 in Th1 and Th2 subtypes of CD4+ lymphocytes

Folia Histochem Cytobiol. 2000;38(1):21-3.

Abstract

Different cytokine profiles allow to divide the CD4+ lymphocytes into Th1, Th2 and Th0 subtypes. It has been observed that the Th2 cells are more efficient supporters for HIV-1 replication than the Th1 cells. The Th1 and the Th2 cells were isolated from peripheral blood lymphocytes of HIV-1 seronegative individuals and the density of CXCR4 receptors was determined by flow cytometry using antibodies directed against the CXCR4 receptor. Flow cytometric analysis revealed higher expression of the HIV-1 co-receptor CXCR4 on Th2 cells than on the Th1, which might explain better replication of HIV-1 viruses in the Th2 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies
  • Antigens, Surface / analysis
  • Antigens, Surface / immunology
  • CD4 Lymphocyte Count / methods*
  • Flow Cytometry
  • HIV Infections / immunology
  • HIV-1
  • Humans
  • Receptors, CXCR4 / analysis*
  • Receptors, CXCR4 / immunology
  • Th1 Cells / chemistry
  • Th1 Cells / cytology*
  • Th1 Cells / virology
  • Th2 Cells / chemistry
  • Th2 Cells / cytology*
  • Th2 Cells / virology

Substances

  • Antibodies
  • Antigens, Surface
  • Receptors, CXCR4