Evaluation of T-cell response to CD3 plus CD28 monoclonal antibodies in HIV-1 infected subjects treated with highly active antiretroviral therapy

J Biol Regul Homeost Agents. 2000 Jan-Mar;14(1):38-40.

Abstract

To investigate whether highly active antiretroviral therapy (HAART) could improve CD28 molecule expression and CD28-costimulation pathway function we tested the effect of CD28-costimulation on T cell receptor/CD3 induced proliferative responses in a group of HIV-1-infected subjects with CD4+ cells>200/mmc before and after HAART. CD3-mediated responses are recovered or improved after HAART. However the ability of potentiating the responses through CD28-costimulation seemed conserved before therapy and decreased in parallel with increase of response to CD3 alone. These results confirm the integrity of CD28-pathway of costimulation in patients with CD4+ cells>200/mmc and suggest an inverse correlation between magnitude of response to CD3 alone and increase of CD3 response due to anti-CD28 addition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / drug therapy*
  • Acquired Immunodeficiency Syndrome / immunology
  • Anti-HIV Agents / therapeutic use*
  • Antibodies, Monoclonal / immunology*
  • CD28 Antigens / physiology*
  • CD3 Complex / immunology*
  • HIV-1*
  • Humans
  • Lymphocyte Activation
  • T-Lymphocytes / immunology*

Substances

  • Anti-HIV Agents
  • Antibodies, Monoclonal
  • CD28 Antigens
  • CD3 Complex