Comparative killing rates of fluoroquinolones and cell wall-active agents

Antimicrob Agents Chemother. 2000 May;44(5):1377-80. doi: 10.1128/AAC.44.5.1377-1380.2000.

Abstract

Killing rates of fluoroquinolones, beta-lactams, and vancomycin were compared against Enterobacteriaceae, Staphylococcus aureus, pneumococci, streptococci, and Enterococcus faecalis. The times required for fluoroquinolones to decrease viability by 3 log(10) were 1.5 h for Enterobacteriaceae, 4 to 6 h for staphylococci, and >/=6 h for streptococci and enterococci. Thus, the rate of killing by fluoroquinolones is organism group dependent; overall, they killed more rapidly than beta-lactams and vancomycin.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Anti-Infective Agents / pharmacology*
  • Cell Wall / drug effects
  • Enterobacteriaceae / drug effects
  • Enterococcus faecalis / drug effects*
  • Fluoroquinolones
  • Lactams
  • Microbial Sensitivity Tests
  • Staphylococcus aureus / drug effects*
  • Streptococcus / drug effects
  • Time Factors
  • Vancomycin / pharmacology

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Fluoroquinolones
  • Lactams
  • Vancomycin