Fluconazole-induced agranulocytosis with eosinophilia

Pharmacotherapy. 2000 Apr;20(4):484-6. doi: 10.1592/phco.20.5.484.35058.

Abstract

Fluconazole is a commonly prescribed antifungal agent with a favorable safety profile. A patient experienced agranulocytosis and eosinophilia associated with the drug. Similar bone marrow-suppressive effect due to the azoles is rarely described in the English-language literature.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Agranulocytosis / chemically induced*
  • Antifungal Agents / adverse effects*
  • Antifungal Agents / therapeutic use
  • Eosinophilia / chemically induced*
  • Fluconazole / adverse effects*
  • Fluconazole / therapeutic use
  • Humans
  • Leukocyte Count / drug effects
  • Male
  • Meningitis, Cryptococcal / drug therapy

Substances

  • Antifungal Agents
  • Fluconazole