Regulation of T cell function by NK cell receptors for classical MHC class I molecules

S Ugolini; E Vivier

doi:10.1016/s0952-7915(00)00090-x

Regulation of T cell function by NK cell receptors for classical MHC class I molecules

Curr Opin Immunol. 2000 Jun;12(3):295-300. doi: 10.1016/s0952-7915(00)00090-x.

Authors

S Ugolini¹, E Vivier

Affiliation

¹ Centre d'Immunologie de Marseille-Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Campus Universitaire de Luminy, Marseille, 13288, France.

PMID: 10781402
DOI: 10.1016/s0952-7915(00)00090-x

Abstract

Inhibitory receptors for MHC class I molecules were initially characterised on NK cells. Human and mouse NK cell receptors (NKRs) are also expressed on T cells, predominantly on a subset of memory-phenotype CD8(+) T cells. This review focuses on the precise determination of interactions between NKRs and MHC class I, as well as on the unexpected in vivo function of NKRs on T cells.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antigens, CD*
Antigens, Ly*
CD8-Positive T-Lymphocytes
Histocompatibility Antigens Class I / metabolism*
Humans
Immunologic Memory
Killer Cells, Natural*
Lectins, C-Type
Leukocyte Immunoglobulin-like Receptor B1
Membrane Glycoproteins / metabolism
Mice
Receptors, Immunologic / metabolism*
Receptors, KIR
Receptors, NK Cell Lectin-Like
T-Lymphocytes / immunology*

Substances

Antigens, CD
Antigens, Ly
Histocompatibility Antigens Class I
LILRB1 protein, human
Lectins, C-Type
Leukocyte Immunoglobulin-like Receptor B1
Membrane Glycoproteins
Receptors, Immunologic
Receptors, KIR
Receptors, NK Cell Lectin-Like