Abstract
Lymphomas of mucosa-associated lymphoid tissues (MALTomas) arising from the thymus are extremely rare. In this case report, we describe a 36-year-old woman with an 11-year history of Sjögren syndrome who was found to have a thymic MALToma coexisting with a gastric MALToma. Both tumors shared similar histologic features, showing clusters of centrocytic-like B cells, lymphoepithelial lesions, and prominent plasmacytic differentiation. They also showed the following identical immunohistochemical features: CD20(+), IgA/lambda(+), CD5(-), and CD43(-). Molecular studies using polymerase chain reaction methods revealed monoclonal gene rearrangement of the immunoglobulin heavy chain in the gastric MALToma, but not in the thymic MALToma. The possible pathogenesis of this unusual case is discussed.
MeSH terms
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Adult
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Biomarkers, Tumor / metabolism
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Fatal Outcome
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Female
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Humans
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Immunohistochemistry
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Lymphoma, B-Cell, Marginal Zone / complications
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Lymphoma, B-Cell, Marginal Zone / diagnostic imaging
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Lymphoma, B-Cell, Marginal Zone / metabolism
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Lymphoma, B-Cell, Marginal Zone / pathology*
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Lymphoma, B-Cell, Marginal Zone / surgery
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Neoplasm Recurrence, Local
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Neoplasms, Multiple Primary / complications
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Neoplasms, Multiple Primary / diagnostic imaging
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Neoplasms, Multiple Primary / metabolism
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Neoplasms, Multiple Primary / pathology*
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Neoplasms, Multiple Primary / surgery
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Sjogren's Syndrome / complications*
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Stomach Neoplasms / complications
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Stomach Neoplasms / diagnostic imaging
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Stomach Neoplasms / metabolism
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Stomach Neoplasms / pathology*
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Stomach Neoplasms / surgery
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Thymus Neoplasms / complications
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Thymus Neoplasms / diagnostic imaging
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Thymus Neoplasms / metabolism
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Thymus Neoplasms / pathology*
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Thymus Neoplasms / surgery
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Tomography, X-Ray Computed