[Phenotypic expression of Lp(a) in Spanish children and adolescents]

J A Gómez Gerique; D López Martínez; P Cancelas; M T Montoya; M D Gutiérrez; A Porres

doi:10.1016/s0025-7753(00)71173-0

[Phenotypic expression of Lp(a) in Spanish children and adolescents]

Med Clin (Barc). 2000 Jan 15;114(1):13-5. doi: 10.1016/s0025-7753(00)71173-0.

[Article in Spanish]

Authors

J A Gómez Gerique¹, D López Martínez, P Cancelas, M T Montoya, M D Gutiérrez, A Porres

Affiliation

¹ Departamento de Bioquímica Clínica, Fundación Jiménez Díaz, Madrid. [email protected]

PMID: 10782454
DOI: 10.1016/s0025-7753(00)71173-0

Abstract

Background: To know the distribution of phenotypes Lp(a) in an young population.

Methods: Lipoprotein levels, lipoprotein(a), apolipoproteins and the Lp(a) phenotypes were determined in 105 children, selected according to their cholesterol concentrations.

Results: The Lp(a) concentrations were significantly higher in group with low molecular weight respect to group with high molecular weight. The most frequent isoform was S3.

Conclusions: The Lp(a) concentrations correlate inversely with the molecular weight of Apo(a) isoforms.

Publication types

English Abstract

MeSH terms

Adolescent
Apolipoproteins A / blood
Apolipoproteins A / genetics
Apolipoproteins B / blood
Apolipoproteins B / genetics
Child
Child, Preschool
Cholesterol / blood
Electrophoresis, Agar Gel / methods
Female
Gene Expression / genetics*
Humans
Immunoblotting
Lipoprotein(a) / blood
Lipoprotein(a) / genetics*
Male
Molecular Weight
Myocardial Ischemia / blood
Myocardial Ischemia / genetics
Phenotype
Population Surveillance
Protein Isoforms / genetics
Spain

Substances

Apolipoproteins A
Apolipoproteins B
Lipoprotein(a)
Protein Isoforms
Cholesterol