Serendipitous synthesis of novel dehydro- and dechloro-pseudomycin B (PSB) derivatives

Bioorg Med Chem Lett. 2000 Apr 17;10(8):775-8. doi: 10.1016/s0960-894x(00)00096-2.

Abstract

The syntheses and preliminary investigation of antifungal activities of two dehydro PSB derivatives 8 and 10 as well as one 3-imido-9-dechloro PSB analogue 13 are described.

MeSH terms

  • Antifungal Agents / chemical synthesis
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology
  • Chlorine / chemistry
  • Microbial Sensitivity Tests
  • Peptides, Cyclic / chemical synthesis*
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / pharmacology
  • Water / chemistry

Substances

  • 3-imido-9-dechloropseudomycin B
  • Antifungal Agents
  • Peptides, Cyclic
  • Water
  • Chlorine