An efficient protocol for the preparation of primary alcohols bearing a beta-chiral center via an oxazolidinone auxiliary mediated resolution, and application to the synthesis of 4,4-disubstituted piperidine substance P antagonists

J Org Chem. 2000 Apr 21;65(8):2615-8. doi: 10.1021/jo9918246.

Authors

R T Lewis¹, T Ladduwahetty, K J Merchant, L E Keown, L Hitzel, H Verrier, G I Stevenson, A M MacLeod

Affiliation

¹ Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, UK.

PMID: 10789488
DOI: 10.1021/jo9918246

No abstract available

MeSH terms

Alcohols / chemical synthesis*
Calorimetry
Diazonium Compounds / chemistry
Magnetic Resonance Spectroscopy
Oxazoles / chemical synthesis*
Piperidines / chemical synthesis*
Piperidines / pharmacology
Stereoisomerism
Substance P / antagonists & inhibitors*

Substances

Alcohols
Diazonium Compounds
Oxazoles
Piperidines
Substance P