Interpretation of the weight of scientific evidence depends upon the framing of at least two competing propositions to weigh against each other. It is the stage of framing propositions that is the most difficult aspect of evidence interpretation. The logical structure for case assessment and interpretation has been described by the authors in three previous papers [Cook R, et al. A model for case assessment and interpretation. Science & Justice 1998; 38: 151-156. Cook R, et al. A hierarchy of propositions: deciding which level to address in casework. Science & Justice 1998; 38: 231-239. Cook R, et al. Case pre-assessment and review in a two-way transfer case. Science & Justice 1999; 39: 103-111]. This paper considers the framing of propositions in greater detail, in particular the intermediate stage of exploring less formal explanations. All of the discussion is based on experiences encountered in workshops with caseworking forensic scientists.