[Autosomal dominant polycystosis in the hospital milieu in Dakar (Senegal)]

Dakar Med. 1998;43(2):205-8.
[Article in French]

Abstract

Autosomial dominant polycystic kidney disease (ADPKD) is an hereditary affection transmitted in a autosal dominant pattern with variable penetrancy. Diagnosis is based upon ultrasound examination and/or familial history. The authors present a 8 years retrospective hospital study in order to precise the epidemiological and clinico-biological aspects of ADPKD in Dakar. So 23 patients were studied. The mean age at the diagnosis was 46 years. They were 9 men and 14 women (sex ratio 0.64). A past history of familial nephropathy was found in 52.2% of cases. The circumstances of diagnosis were dominated by lombar pain (52.2%) and hypertension (17.4%) but at examination, blood pressure was high in 34.8% and represent the main factor of worsening the disease. Enlargement of kidney was found in 47.8% and hepatomegaly in 13% of cases. Anemia was particularly common 56.5%. The most frequent extra renal manifestation was the liver cysts and occurs mainly in women. National prevalence of ADPKD and the specific gene should be precise in further studies.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Anemia / etiology
  • Cross-Sectional Studies
  • Female
  • Hepatomegaly / etiology
  • Hospitalization / statistics & numerical data*
  • Hospitals, University
  • Humans
  • Hypertension / etiology
  • Male
  • Middle Aged
  • Polycystic Kidney, Autosomal Dominant / complications
  • Polycystic Kidney, Autosomal Dominant / diagnosis*
  • Polycystic Kidney, Autosomal Dominant / epidemiology*
  • Polycystic Kidney, Autosomal Dominant / genetics
  • Prevalence
  • Retrospective Studies
  • Senegal / epidemiology
  • Sex Distribution