Abstract
Bioactivity guided isolation of Abutilon indicum yielded eugenol [4-allyl-2-methoxyphenol], which was found to possess significant analgesic activity. At doses of 10, 30, and 50 mg/kg body weight, eugenol exhibited 21.30 (p < 0.05), 42.25 (p < 0.01) and 92.96% (p < 0.001) inhibition of acetic acid induced writhing in mice. At a dose of 50 mg/kg body weight, eugenol showed 33.40% (p < 0.05) prolongation of tail flicking time determined by the radiant heat method.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates
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Analgesics / isolation & purification
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Analgesics / pharmacology*
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Animals
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Chromatography, Thin Layer
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Eugenol / analogs & derivatives*
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Eugenol / isolation & purification
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Eugenol / pharmacology
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Hot Temperature
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Male
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Mice
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Oils, Volatile / chemistry
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Pain Measurement / drug effects
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Plants, Medicinal / chemistry*
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Rats
Substances
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Acetates
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Analgesics
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Oils, Volatile
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eugenol-4-allyl-2-methoxyphenol
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Eugenol