Abstract
Some new approaches to the 1,6-methano[10]annulene system are described. The routes were used to prepare 1,6-methano[10]annulene-3-acetic acid and the alpha-methyl analog. The compounds showed antinflammatory and analgesic activity, though less than that of corresponding naphthalene compounds; the possible effect of the chirality of the annulene on the observed biological activity is discussed.
MeSH terms
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Acetates / chemical synthesis
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Acetates / therapeutic use
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Animals
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Anti-Inflammatory Agents / chemical synthesis*
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Anti-Inflammatory Agents / therapeutic use
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Aspirin / therapeutic use
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Bridged-Ring Compounds / chemical synthesis*
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Bridged-Ring Compounds / therapeutic use
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Carrageenan
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Edema / chemically induced
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Edema / drug therapy
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Mice
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Phenylbutazone / therapeutic use
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Rats
Substances
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Acetates
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Anti-Inflammatory Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Bridged-Ring Compounds
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Carrageenan
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Phenylbutazone
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Aspirin