Palladium-catalyzed intermolecular coupling of aryl halides and amides

Org Lett. 2000 Apr 20;2(8):1101-4. doi: 10.1021/ol005654r.

Abstract

[formula: see text] The first general intermolecular C-N bond-forming reactions between aryl halides and amides were realized using a palladium catalyst with Xantphos as the ligand. Aryl triflates, carbamates, and sulfonamides are also viable substrates for the amidations, which proceed at 45-110 degrees C with 1-4 mol% of Pd catalyst in 66-99% yields and exhibit good functional group compatibility.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amides / chemistry*
  • Catalysis
  • Chromatography, Gas
  • Halogens / chemistry*
  • Palladium / chemistry*

Substances

  • Amides
  • Halogens
  • Palladium