T cell-mediated paraneoplastic ganglionitis--an autopsy case

Acta Neuropathol. 2000 May;99(5):599-602. doi: 10.1007/s004010051168.

Abstract

A 57-year-old woman presented with subacute sensory, ataxic neuronopathy. Clinical investigation revealed a right-sided non-small-cell lung cancer. Serum investigation for specific antineuronal antibodies was negative. Histology showed T lymphocytic infiltrates in dorsal root ganglia. The observed histological pattern is similar to that described in antibody-positive cases. Thus, these findings suggest similar pathways in specific antineuronal antibody-negative and -positive cases of paraneoplastic subacute sensory neuronopathy.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies / immunology
  • ELAV Proteins
  • Fatal Outcome
  • Female
  • Ganglia, Spinal / immunology
  • Ganglia, Spinal / pathology*
  • Humans
  • Middle Aged
  • Nerve Tissue Proteins / analysis
  • Paraneoplastic Polyneuropathy / immunology
  • Paraneoplastic Polyneuropathy / pathology*
  • RNA-Binding Proteins / analysis
  • T-Lymphocytes / immunology*

Substances

  • Autoantibodies
  • ELAV Proteins
  • Nerve Tissue Proteins
  • RNA-Binding Proteins